George Little (Jonathan Lipnicki) is a young kid who persuades his parents, Frederick (Hugh Laurie) and Eleanor (Geena Davis) to adopt a younger brother for him. They approach an orphanage for adoption where they meet a talking mouse, Stuart (Voice - Michael J. Fox). They adopt Stuart, but George refuses to accept him as his younger brother. After a while, George and Stuart bond with each other and soon Stuart becomes a precious part of the Little family. One day, Stuart's parents arrive, and he leaves with them which actually was a conspiracy set up by Snowbell, the family cat. Help Stuart claim back his life as he fights with Snowbell and the alley cats to come back to Little family.
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