Based on the fictional Marvel Comics, it is a story of Peter parker (Tobey Maguire) who is bitten by a spider while his visit at genetics laboratory of Columbia University with his best friend Harry Osborn (James Franco) and his secret crush Mary Jane Watson (Kirsten Dunst). It is the life journey of Peter Parker, who ends up being Spider Man. Norman Osborn, a scientist and Harry's father is trying to preserve his company, knowing that its loss will mean the end to his business. He carries out an experiment on himself using performance enhancing drug on himself which alters his ego into Green Goblin. He asks Spider Man to team up with him, but Spider Man refuses to be a part of it. This makes Green Goblin furious igniting a war between the two where only one will survive till the end.
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